ODIN Bio & Science
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Science

Ingredients in numbers.
Claims with evidence.

The ingredients and technology we work with, and the research data behind them.

Fig. 05Mangifera indica L. — leaf venation

Ingredients

Three core ingredients

Mango Leaf Extract

Mangifera Indica Leaf Extract

27.56 mg/gMangiferin · HPLC assay

Sourced from pesticide-free apple mango leaves in Geumsan, Korea. Standardized to a high level of mangiferin and backed by a patent and an SCI paper.

Origin
Geumsan, Korea · pesticide-free
Part
Leaf
Assay
HPLC · R² 0.9997
Use
SKULD foam · hand cream · hair line (planned)

Smilax China Extract

Smilax China Root Extract

SoothingCalming · skin barrier

A traditionally used botanical, developed as a soothing and barrier-care ingredient for sensitive skin.

Part
Root
Concept
Soothing · barrier support
Use
Skin repair cream (in development)

Hemp Seed Extract

Cannabis Sativa Seed Extract

OmegaEssential fatty acids

Derived from seeds and free of psychoactive compounds. Omega fatty acids support moisture and oil-water balance.

Part
Seed
QC
THC · CBD not detected (COA)
Use
LIPIDERM (launch 2027)

Delivery technology

Good actives,
where they’re needed

TDS (transdermal delivery system) loads actives into nanostructured lipid carriers (NLC) that pass the skin barrier. Our aim is to deliver mangiferin to the hair follicle, activating Wnt/β-catenin signaling and suppressing DKK1.

Stratum corneum
Epidermis
Dermis & follicle
≤300nm

Particle size target · now 430 nm

≥92%

Encapsulation efficiency target

≥180%

Skin penetration target

  1. NLC composition screeningOptimal lipid ratio and surfactant selection
  2. Formulation optimizationParticle size and PDI control process
  3. Stability testingLong-term and accelerated stability, skin absorption

Evidence

Research data

Key results confirmed at the ingredient stage.

Mangiferin standardization

27.56mg/g

HPLC assay (R² = 0.9997). 183% of target.

Reduction in hair-related gene expression (vs. control)

DKK190%
SRD5A160%
SRD5A250%

Safety · antioxidant

>90%

Dermal papilla cell viability, no toxicity. ABTS radical scavenging 93.4% (100 μg/mL).

PatentKR 10-2638147Mango leaf extract composition
Journal · 2021Kor. J. Herbol.Gene expression in dermal papilla cells
SCI · 2022Animal Cells & SystemsWnt signaling and hair growth

※ In-vitro data at the ingredient stage. Not a claim of finished-product efficacy.